![]() ![]() ![]() We also found that PXS and PGS were both significantly ( P < 0.0001) and positively associated with the total number of incident diseases. For instance, the hazard ratio of COPD and obesity for individuals in the top T2D PXS deciles was 2.82 (95% CI 2.39–3.35, P = 4.00 × 10 −33) and 2.54 (95% CI 2.24–2.87, P = 9.86 × 10 −50), respectively, compared to the remaining population. Compared to the remaining population, individuals in the top deciles of PGS and PXS had particularly high risks of developing chronic diseases. There were 4% and 8% of individuals in the bottom deciles of PXS and PGS, respectively, who were prediabetic at baseline but had low risks of T2D and other chronic diseases. In addition to predicting incident T2D, PXS and PGS were significantly and positively associated with the incidence of all 7 other chronic diseases. PXS was associated with higher levels of clinical risk factors including BMI, systolic blood pressure, blood glucose, triglycerides, and HbA1c in individuals without overt or diagnosed T2D. ![]()
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